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    <b>Do side effects of estradiol go away?</b> Transdermal estradiol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away : headache. breast pain or tenderness.
    <b>Is estriol safer than estradiol?</b> Estriol has been found to provide some of the protection without the risks associated with stronger estrogens. Although estriol appears to be much safer than estrone or estradiol, its continuous use in high doses may have a stimulatory effect on both breast and endometrial tissue.
    <b>How long should HRT be taken?</b> Most experts agree that if HRT is used on a short-term basis (no more than five years), the benefits outweigh the risks. If HRT is taken for longer, particularly for more than 10 years, you should discuss your individual risks with your GP and review them on an annual basis.
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